Palladium-Catalyzed Fluorinated Olefination of Aromatics
Xin Liu1, Yalong Li1, Yilian Song1, Jingyi Guo1, Zechao Liu1, Yingsheng Zhao1,2（赵应声）*
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R.China
2School of Chemistry and Chemical Engineering,Henan Normal University, Xinxiang 453000, P. R. China
Org. Lett. 2024, 26, 51, 11173–11178
Abstract: Palladium-mediated, ligand-promoted C–H fluorinated olefination of aromatic derivatives is reported employing 2-bromo-3,3,3-trifluoropropene (BTP) as the fluorinating reagent. Bioactive compounds, such as Isatin, exhibited excellent compatibility with this reaction, underscoring the significance of this methodology for the synthesis of important derivatives.
Article information: //doi.org/10.1021/acs.orglett.4c04254
