Palladium-catalyzed cascade cyclization of isocyanides with di-(o-iodophenyl)sulfonylguanidines: access to heterocyclic fused quinazolines
Shen Ge1, Yi-Ming Zhu1, Xiao-Ping Xu1,2（徐小平）*, You Zi3（訾由）*,Shun-Jun Ji1（纪顺俊）*
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China.
2Innovation Center for Chemical Science, Soochow University, Suzhou 215123, P. R. China
3School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, P. R. China.
Chem. Commun., 2024, 60, 14613-14616
Abstract: A palladium-catalyzed cascade cyclization reaction of di-o-iodophenyl sulfonylguanidines with isocyanides for the efficient and selective synthesis of 5- or 6-membered heterocyclic fused quinazolines has been developed. Diverse functional groups are well tolerated, and this method has been successfully applied to a larger scale synthesis.
Article information: //doi.org/10.1039/D4CC04084H
