Nickel-catalyzed silylation of aryl thianthrenium salts with silylzinc pivalates
Zhenfeng Tian, Zhili Cui, Ying Hu, Jiabin Zhang, Liangjie Ruan, Jie Li*
Key Laboratory of Organic Synthesis of Jiangsu Province, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Suzhou, China
Chem. Commun., 2024, 60, 14593-14596
Abstract: A nickel-catalyzed C–S silylation of aryl thianthrenium salts with salt-stabilized silylzinc pivalates is disclosed, thus allowing us to rapidly incorporate silyl motifs into aromatics in a site- and chemoselective fashion. This method is distinguished by its ample scope and facile derivatizations of the aryl silanes for increasing functional molecular complexity. Moreover, modular installation of silyl groups into pharmaceutically active molecules provides a new platform for the synthesis of sila-drugs.
Article information: //pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc05395h
