A high-entropy coordination cage featuring an Au-porphyrin metalloligand for the photodynamic therapy of liver cancer
Feng-Lin Cao1, Ze-Sheng Zhang1, Meng-Lin Dong1, Ye Ning1, Wen-Hua Zhang1（张文华）, * Yiming Mao2*, David J. Young3
1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
2Department of Thoracic Surgery, Suzhou Kowloon Hospital,Shanghai Jiao Tong University School of Medicine, Suzhou 215028, China.
3James Watt School of Engineering, Glasgow University, University Avenue, Glasgow, G12 8QQ, UK
Chem. Commun.,2025, 61, 6663-6666
Abstract: We report a Pd-based hexagonal prismatic coordination cage of Pd-TMPP(Au) featuring a highly entropic ligand combination,viz. H2TMPP, TMPP(Pd), and TMPP(Au) metalloligands to yield double-arrow-shaped polycrystals. Pd-TMPP(Au) exhibits concentration-dependent cytotoxicity against hepatocellular carcinoma cell lines HuH-7, Hep-G2, and PLC/PRF/5, which is augmented by light irradiation.
Article information: //doi.org/10.1039/D5CC00750J
